Appropriate treatment of sleep disorders may benefit both patients and their caregivers.Īntidepressants with hypnotic action, such as trazodone, have played important roles in treating the elderly with sleep disorders, particularly in patients with dementia 1. In the study of Grace and colleagues, in which the use of hypnosedative drugs was recorded in less than 30% of patients with sleep disorders, the authors argued that there was reluctance by doctors to use hypnotic drugs in demented patients with sleep disorders 5. Some studies have shown that damage to cholinergic neurons may contribute to changes in the sleep of patients with Alzheimer's disease (AD) 1.Įpidemiological surveys conducted in patients with AD have identified a prevalence of sleep disorders in up to 40% of patients with any stage of the disease 3.Ī longitudinal study conducted with 76 elderly demented patients over two years revealed that 24% of study participants used a hypnosedative drug chronically, increasing from 3 to 17% in the first year, and remaining high at 13% in the second year 4.
The origin of sleep disorders in dementia is usually multifactorial, resulting from pathophysiological changes associated with the disease itself, sensory deprivations such as a reduction in auditory and visual acuity, and changes in environmental stimuli such as light. These sleep disorders often contributes to institutionalization 2. Sleep disorders are one of the major complications related to dementia and cause significant impacts on functionality and quality of life in elderly patients 1. Palavras-chave: sono, demência, doença de Alzheimer, trazodona, antidepressivos. A trazodona mostrou-se ser uma boa opção no tratamento de idosos com demência e DS associado. A trazodona foi a mais utilizada (N=35), com evidência de melhora de 65,7%. Aproximadamente 85% usaram fármacos hipnossedativos.
A maioria (114 64%) tinham diagnóstico de DA. No período de um ano de estudo, 68 (38,2%) tiveram DS. Nós avaliamos 178 idosos com doença de Alzheimer (DA) e outras demências, clinicamente apresentando DS e que foram tratados com medicações hipnossedativas. O objetivo desse estudo é apresentar um perfil do uso da trazodona em pacientes com demência e com DS, bem como revisar o cloridrato de trazodona no DS. O uso de antidepressivos com ação hipnótica, como a trazodona, tem um papel importante nesses casos. Key words: sleep, dementia, Alzheimer's disease, trazodone, antidepressant.ĭistúrbios do sono (DS) em pacientes com demência são muito comuns na prática clínica. Trazodone has been shown to be a good option for treatment of the elderly with dementia and associated SD. Trazodone was the most commonly used drug among patients (N = 35), with an effectiveness of 65.7%. Approximately 85% of patients with SD used hypnosedative drugs. Most patients (114 64%) had a diagnosis of Alzheimer's disease. In the one-year period comprising the study, 68 (38.2%) of the 178 had sleep disorders. We evaluated 178 elderly patients with Alzheimer's disease and other dementias, clinically presenting SD and treated with hypnosedative medications. The aim of this study is to present a profile of the use of trazodone in demented patients with SD, as well as a review of trazodone hydrochloride in SD. The use of antidepressants with hypnotic actions, such as trazodone, plays an important role in these cases. VProfessor of Pharmacy, Department of Health Sciences (UnB)ħ0840-901 Brasilia DF - disorders (SD) in patients with dementia are very common in clinical practice. IVPharmacists specializing in Clinical Pharmacy (UnB) IIPublic Health and Aging Research Group, Oswaldo Cruz Foundation René Rachou Institute, Belo Horizonte MG, Brazil IAssistent Geriatrician, Geriatric Medical Centre (CMI), University Hospital (HuB), Brasilia University (UnB), Brasilia DF, Brazil Trazodona para o tratamento de distúrbios do sono em demência: um estudo aberto, observacional e de revisãoĮinstein Francisco Camargos I Marcela Basso Pandolfi I Marco Polo Dias Freitas I, II Juliana Lima Quintas III Juliana de Oliveira Lima IV Leandra Camapum Miranda IV Luciano Wanderley Pimentel IV Patricia Medeiros-Souza V Trazodone for the treatment of sleep disorders in dementia: an open-label, observational and review study
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